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In contrast to the expression of Fos, phosphorylation of ERK is a highly dynamic process and only occurs 5—20 minutes after neuronal activation. In experienced males, Fos can be induced by conditioned contextual cues associated with prior sexual experience Balfour et al,

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  1. A similar response has previously been observed with repeated exposure to amphetamine or other drugs of abuse Lett, , Shippenberg and Heidbreder, , Shippenberg et al. Although it is known that both drugs of abuse and sexual behavior activate mesolimbic brain areas, it is currently unclear whether drugs of abuse influence the same neurons that mediate sexual behavior.