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Growing evidence now supports the idea that LTP and LTD are required for generation of whisker barrel field maps in the primary somatosensory cortex and ocular dominance columns in the primary visual cortex, both involving reorganization of thalamic inputs to layer 4. Plasticity of ocular dominance columns in monkey striate cortex.

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Clinical considerations Identifying the molecular basis for synaptic pruning in adolescence could have wide ranging clinical ramifications. Develop Med Child Neurol.

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  1. Molecular sites of interaction between environmental factors, such as alcohol and stress, and glutamate receptor mediated plasticity are considered. Growing evidence now supports the idea that LTP and LTD are required for generation of whisker barrel field maps in the primary somatosensory cortex and ocular dominance columns in the primary visual cortex, both involving reorganization of thalamic inputs to layer 4.