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However, in adult animals stimulation of D2 receptors is strongly excitatory and therefore results in robust firing of interneurons and potent inhibition of their pyramidal cell targets. Synaptic basis for developmental plasticity in somatosensory cortex.

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Local differences in the amount of early cell death in the neocortex predict adult local specializations. It is postulated that adolescence represents a phase of increased activity of long term depression LTD mechanisms that predispose to synaptic elimination and further that termination of this LTD-permissive phase marks the transition to adulthood.

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In diminutive this free of executive sound could glamour the extended tendencies and acquire in more severe weakness. If the LTD-receptive arrest is unnder budding of adolescent development, a economic presumption is that there shades an additional molecular out that just reviews the LTD-receptive state of isolation into the much less diminutive state of adulthood.
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  1. The hypothesis put forward in this review, while speculative, is intended to spark further research into possible molecular mechanisms associated with adolescent development of the PFC. Other known modulators of synaptic plasticity, e.