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Another presynaptic mechanism for alcohol-induced increase in glutamate transmission could be via activation of D1 receptors Deng et al. Natural rewards are critical for survival and include food, water, and sex.

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  1. This membrane depolarization occurs via activation of AMPA receptors, which are described as workhorses amongst the glutamate receptors. In the subsequent section, we will discuss the effects of blocking glutamatergic transmission using pharmacological compounds on behavioral measures of drug reward.