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Abstract Neurophysiologic processes underlie the uncontrolled, compulsive behaviors defining the addicted state. Within this framework, future targets for pharmacologic treatment are suggested.

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The role of mesocorticolimbic dopaminergic and glutaminergic pathways, intracellular mechanisms, and relevant brain regions in compulsive drug drive and inhibitory dyscontrol will be the focus of these sections on drug relapse. A short film by Stephanie Sinclair and Jessica Dimmock.

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  1. Double-blind, placebo-controlled studies of carbamazepine demonstrated limited efficacy in the treatment of cocaine dependence, 63 - 65 however, and dopaminergic antagonists e. Using functional magnetic resonance imaging fMRI , Breiter and colleagues 29 administered cocaine to cocaine-addicted subjects while their brains were being scanned.

  2. We just launched a pot-still vodka, as well as the juniper-casked gin and both are doing really, really well.