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For reasons that are not completely understood, this method can be used with most D2 receptor radiotracers but not with radiotracers that bind to the D1 receptor. These alterations in dopamine transmission have clinical relevance, and have been shown to correlate with cocaine-seeking behavior and response to treatment for cocaine dependence. Among the possible mechanisms that are known to regulate striatal dopamine release is dynorphin acting at the kappa receptor.

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This article has been cited by other articles in PMC. Thus, a better understanding of the mechanisms behind blunted dopamine release would be expected to have implications for treatment development.

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Free galleries of couples having sex

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  1. However, the mechanisms contributing to the hypodopaminergic state in cocaine addiction remain unknown.

  2. This is performed by imaging with radiotracers that are sensitive to changes in extracellular dopamine, and obtaining scans before and after the administration of a psychostimulant such as amphetamine or methylphenidate.

  3. Furthermore, studies in humans and animals show that dynorphin is significantly upregulated following chronic cocaine exposure, and that this effect is long lasting for review, see Koob and Le Moal, ; Muschamp and Carlezon, , which could account for the decrease in dopamine signaling seen after 2 weeks of abstinence in the human imaging studies.

  4. Among the possible mechanisms that are known to regulate striatal dopamine release is dynorphin acting at the kappa receptor.