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For reasons that are not completely understood, this method can be used with most D2 receptor radiotracers but not with radiotracers that bind to the D1 receptor. These alterations in dopamine transmission have clinical relevance, and have been shown to correlate with cocaine-seeking behavior and response to treatment for cocaine dependence. Among the possible mechanisms that are known to regulate striatal dopamine release is dynorphin acting at the kappa receptor.
This article has been cited by other articles in PMC. Thus, a better understanding of the mechanisms behind blunted dopamine release would be expected to have implications for treatment development.
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